Biologically Motivated Computational Modeling: Contribution to Risk Assessment
نویسندگان
چکیده
منابع مشابه
Biologically motivated computational modeling: contribution to risk assessment.
The article highlighted in this issue is ‘‘Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose Response Predictions Derived from Biologically Motivated ComputationalModelingofaCombinedRodent andHuman Dataset,’’ by Rory Conolly, Julia Kimbell, Derek Janszen, Paul Schlosser, Darin Kalisak, Julian Preston, and Frederick Miller. In the featured article, Conolly et al. describe the de...
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Chloroform is a nongenotoxic-cytotoxic carcinogen in rodents. As such, events related to cytotoxicity are the driving force for cancer induction. In this paper we extended an existing physiologically based pharmacokinetic (PBPK) model for chloroform to describe a plausible mechanism linking the hepatic metabolism of chloroform to hepatocellular killing and regenerative proliferation. The key as...
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1National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC 20460, USA 2Department of Occupational and Environmental Health, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada H3T 1A8 3National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protect...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2004
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfh282